Formulation and efficiency control of a topical solution with healing properties based on aqueous extract of trunk bark of Vernonia conferta (Asteraceae) in Wistar strain rats

Abstract

Introduction: Vernonia conferta is a species used by the Cameroonian populations in the management of wounds. The objective of this work was to formulate a topical solution from aqueous extract of V. conferta and to evaluate the healing activity of this solution.

Methodology: the study was experimental. The plant material consisted of trunk bark of V. conferta. The solution was formulated from the extract obtained by decoction of 600 g of bark powder in 1 liter of water. The decoction was dried in an oven, then 10 g of powder was dissolved in 100 ml of distilled water. The pH was measured. The effectiveness check consisted of the evaluation of the healing properties on wounds induced by excision in the Wistar rat compared to those of to the 10% povidone-iodine solution (BETADINE 10%).

Results: the formulated solution was named ABEYAKIN 10%, it was brown in color, with a characteristic and homogeneous odor. The pH measured at 25.9°C was 6.9. Rats treated with ABEYAKIN 10% solution showed the fastest healing (p < 0.001) observed on the fourteenth day, compared those treated with BETADINE 10% ( sixteenth day).

Conclusion: these results demonstrate that the topical solution based on aqueous extract of V. conferta bark has healing activity in Wistar rats.